CD4 anticorps (mFluor™450)

N° du produit ABIN7077202

L’anticorps Souris Monoclonal anti-CD4 a été validé pour FACS. Il convient pour détecter CD4 dans des échantillons de Humain.

Aperçu rapide pour CD4 anticorps (mFluor™450) (ABIN7077202)

Antigène: CD4

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD4 est conjugé à/à la mFluor™450

Application: Flow Cytometry (FACS)

Classe de qualité: GMP Grade

Clone: SK3

Détail du produit anti-CD4 anticorps (mFluor™450)

Fonction: CD4 mFluor450 Antibody

Attributs du produit: The clone SK3, a mouse monoclonal antibody selectively binds with a 55-59kD type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. CD4 contains four extracellular Ig-like domains (D1-D4). The epitope for SK3 is located within the D3 domain of the protein, which has a structure resembling an Ig variable domain. Expression of CD4 is observed in subsets of T lymphocytes, monocytes, macrophages, and dendritic cells. Through interaction of MHC-II, CD4 facilitates cell-cell interaction, thymic differentiation, and activation of downstream signaling cascades. HIV infection of T-cells is instigated through binding of HIV to CD4. Binding of SK3 antibody blocks HIV infection through CD4 and also blocks the mixed lymphocyte reaction (MLR).

Purification: Purified

Pureté: >95 %

Immunogène: Human peripheral blood T cells

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS pH 7.2, 0.2 % (w/v) BSA, 0.09 % (w/v) sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: 2-8°C, Conjugated antibodies should never be frozen.

Détails sur CD4

Antigène: CD4

Autre désignation: CD4

ID gène: 920

NCBI Accession: NM_000616

UniProt: P01730

Pathways: TCR Signaling, Maintenance of Protein Location, CXCR4-mediated Signaling Events